Sishu Fertility Clinic

Difference between an IUI and IVF

Difference between an IUI and IVF

When it comes to fertility treatments, Intrauterine Insemination (IUI) and In Vitro Fertilization (IVF) are two commonly discussed options. While both help couples with pregnancy, they differ significantly in their procedures, success rates, and complexities. Understanding the key distinctions between IUI and IVF can help individuals and couples make informed decisions regarding their fertility journey. Let’s explore the differences between these two approaches to fertility treatment.

What is IUI? 

Intrauterine Insemination (IUI) is a fertility treatment supporting couples having difficulty conceiving. It involves placing specially prepared sperm directly into the uterus, coinciding with a woman’s ovulation cycle to optimize the chances of fertilization. The process begins with collecting and washing the sperm to enhance its quality, followed by insertion into the uterus via a catheter. Before the procedure, consultations and medical tests are conducted to ensure suitability, potentially involving fertility medications to stimulate ovulation. The actual procedure is brief and minimally discomforting, which allows patients to resume normal activities immediately. Later, a pregnancy test is administered roughly two weeks later to determine success. IUI offers a relatively simple yet effective method to improve pregnancy possibilities for couples struggling with infertility.

What is IVF? 

In vitro fertilization (IVF) is a special way for people who are having trouble getting pregnant to have a baby. Here’s how it works: First, eggs are taken from the woman’s ovaries. Then, these eggs are mixed with sperm from the man in a lab dish. This is where the sperm fertilizes the eggs, creating embryos. These tiny embryos are then carefully put back into the woman’s uterus where they can grow into a baby. This process typically takes about 2 to 3 weeks to complete. IVF is really helpful for couples who are struggling to have a baby on their own. It’s important to know that IVF can be expensive and sometimes involves getting shots and having medical procedures, but it can also bring a lot of joy to families who are hoping for a baby.

What are the differences between IUI and IVF? 

IUI and IVF are two common fertility treatments, each with its own advantages. IUI involves placing washed sperm directly into the uterus, making it less invasive and cheaper than IVF. However, its success rate per cycle is lower, typically 5% to 20%. IVF, on the other hand, is more complex and costly. It involves retrieving eggs, fertilizing them with sperm in a lab, and then transferring embryos into the uterus. IVF offers higher success rates, around 50% per cycle, and is beneficial for issues like blocked fallopian tubes or low sperm count. It also allows for embryo testing and freezing for future use. Ultimately, the choice between IUI and IVF depends on individual circumstances and should be discussed with a fertility specialist.

Let’s explore the table to draw comparisons between IVF and IUI:





Sperm is placed directly into the uterus using a catheter

Eggs and sperm mixed outside the body, resulting in embryos transferred into the uterus


Done in the provider’s office

Involves multiple visits to the clinic or hospital


Less invasive

More invasive


Single procedure or part of a cycle

Involves multiple steps and procedures over a cycle


Hormone level monitoring during ovulation

Daily monitoring with bloodwork and ultrasounds during egg growth


May involve medications to enhance ovulation

Requires medications to stimulate egg production, often with injections

Egg Retrieval     

Not applicable      

Requires surgical egg retrieval under anesthesia

Embryo Transfer

Not applicable     

Involves transferring embryo(s) into the uterus

Pregnancy Testing

After natural conception or IUI, as usual

After embryo transfer, followed by a waiting period

Success Rate 

Generally lower than IVF    

Generally higher than IUI 


Typically less expensive

Typically more expensive  

Suitable Conditions

Ovulation issues, mild male infertility, unexplained infertility

Severe male infertility, blocked fallopian tubes, previous failed IUI, genetic concerns

Genetic Testing Options

Not commonly performed   

Preimplantation genetic testing is possible 

Which one is right for you?

Determining whether IUI or IVF is right for you depends on various factors, including the cause of your infertility, your medical history, and your fertility goals. If you’re experiencing issues with ovulation or unexplained infertility, IUI might be a suitable starting point. It’s less invasive, involves placing washed sperm directly into the uterus, and can be combined with medications to enhance ovulation. However, if you’re facing severe male infertility, blocked fallopian tubes, or have had unsuccessful attempts with IUI, IVF may be recommended. IVF is more invasive but offers higher success rates in certain cases. It involves surgically retrieving eggs, fertilizing them outside the body, and transferring resulting embryos into the uterus. Additionally, if you have concerns about passing on genetic disorders, preimplantation genetic testing available with IVF could be beneficial. Ultimately, consulting with a fertility specialist is crucial to determine the most suitable treatment option tailored to your specific needs and circumstances.

When should you go for IUI?

You should opt for IUI if:

  1. Individuals with male-factor infertility symptoms, such as weak sperm, can consider IUI as a treatment option.
  2. Couples facing challenges due to hectic schedules or physical separation during ovulation may find IUI beneficial.
  3. Those who have undergone unsuccessful attempts with natural conception or less invasive fertility treatments may also opt for IUI to improve their chances of pregnancy.
  4. Those who are considering using donor sperm or have male partners with low sperm motility can explore IUI as a means to enhance their chances of pregnancy.
  5. Individuals who are unable to ovulate normally or have irregular menstrual cycles may benefit from IUI combined with ovulation-inducing medications.

When should you go for IVF?

You should opt for IVF if:

  1. If you’ve been trying to have a baby for a year (if under 35) or six months (if over 35) without success, IVF could be an option.
  2. IVF might help if you have issues like blocked tubes, older age (usually over 38), or fewer eggs.
  3. For conditions such as severe endometriosis, previous failed fertility treatments, or male fertility problems like vasectomy, IVF could work.
  4. If other methods like insemination haven’t worked due to unknown fertility issues, IVF might be a better choice.
  5. If you’re considering advanced techniques like genetic testing of embryos or using donor eggs, sperm, or a surrogate, IVF offers a solution for various infertility challenges.

Which Is More Successful: IUI or IVF?

IVF has higher success rates than IUI because it can handle more complex fertility issues and involves more steps. Factors like age, fertility problems, and previous pregnancies also affect success. Younger patients usually have better chances, and if someone has been pregnant before, it could help. IVF uses advanced techniques to choose the best embryos for implantation, which increases the chances of getting pregnant. It’s especially helpful for older women and can tackle more types of fertility problems, like blocked fallopian tubes.

 IVF also offers extra procedures like ICSI for severe male infertility. Additionally, it allows for genetic testing of embryos before implantation, which helps ensure a healthy pregnancy. However, IUI can still be a good choice for couples with minor issues or specific situations.

What if IUI and IVF don’t work?

Sometimes, starting treatments like IUI or IVF doesn’t lead to pregnancy right away. It might take several tries over months or even years. It’s important to understand that each person’s journey is different, and success rates vary.

 If both IUI and IVF don’t work, couples might consider donor egg IVF. In donor egg IVF, eggs from a donor are fertilized with sperm and then implanted into the uterus. It’s an option for couples when the woman’s eggs aren’t feasible.  It can also be helpful to seek support from therapists or support groups to cope with the stress and sadness. Even if one treatment fails, it doesn’t mean giving up hope. Success rates can improve with persistence and the right support.

Best fertility clinic For IUI & IVF 

If you’re seeking the best fertility clinic for IUI and IVF, look no further than Sishu Fertility Clinic. Our team is dedicated to providing top-notch care and support throughout your fertility journey. Here’s why we stand out:

  1. High Success Rate: With our skilled experts and advanced technologies, we have a high success rate, even for women in their 30s or menopausal phase.
  2. Expert Team: Led by Best fertility Experts, our team comprises highly qualified specialists committed to your well-being. They offer personalized counseling and design tailored solutions based on the latest research.
  3. Individualized Care: We understand that each patient is unique, so we create personalized treatment plans tailored to your specific needs and circumstances.
  4. Affordable Cost: We believe everyone deserves access to quality fertility care, offering international-level treatment at a fraction of the cost compared to going abroad.
  5. Cutting-Edge Technologies: Our clinic is equipped with state-of-the-art facilities and modern technologies to ensure accurate diagnosis and effective treatment.

Don’t let fertility concerns overwhelm you. Choose Sishu Fertility Clinic for compassionate care and successful outcomes. Contact us today to begin your journey towards parenthood.

Take the next step in starting your family journey with Sishu Fertility Clinic. Our experienced experts are here to offer personalized guidance and compassionate care, whether you’re considering IUI, IVF, or other infertility treatments. Contact us now at +977 9828839269 to schedule your consultation and start your journey towards parenthood.

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